The evaluation of hormone levels in the body is recognized by many physicians as an essential component of a diagnostic work-up. Unlike blood or urine hormone testing, saliva analysis assesses the biologically active compounds (free fraction form) at the cellular level.
Salivary hormone analysis represents what is clinically relevant and conveys the patient’s true hormonal activity, especially with multiple samples collected over the course of a day or more. In comparison, blood analysis assesses compounds as they travel through the blood serum, most of which are protein bound. When released from their protein carriers, the compounds become free. Measuring the concentration of non-bioavailable forms in urine or serum has minimal clinical relevance since the data is insufficient as to the concentration of the more significant free hormones in circulation.
Saliva hormones more accurately reflect tissue uptake and response of hormones delivered through the skin in creams or patches. Urine and blood assays significantly underestimate hormones delivered topically, often resulting in overdosing. Health professionals that choose to use topical hormone applications can most effectively monitor these therapies with salivary assays.
As a diagnostic fluid, saliva is the most convenient, non-invasive specimen available for the client. Invasive procedures, such as blood draws, are not just extremely impractical when it comes to acquiring multiple samples; they also cause a stressful event on the body which can promote a release of cortisol, thus skewing the result for one event.
This profile is used to evaluate the adrenal glands and hormone balance. In the event of adrenal exhaustion and imbalances in the reported hormones, underlying causes must be determined through additional lab testing and investigation into environmental and lifestyle factors; while also supporting the endocrine system with therapies and lifestyle modifications.
When the body is under chronic stress, pregnenolone, the precursor to all other steroidal hormones, is diverted to produce cortisol (known as pregnenelone steal or cortisol escape – see Steroidal Hormone Principle Pathways). This is to the detriment of all other steroidal hormones (such as DHEA and its metabolites, including progesterone, testosterone, and the estrogens). As pregnenolone is diverted to cortisol, DHEA depletion begins. The result is an elevated cortisol to DHEA ratio. A normal ratio is approximately 5:1 to 6:1.
Profile #205 includes additional hormones for a more complete view into the impacts of chronic stress on the individual’s core body systems. A vast amount of information can be gathered through this profile.
#205 Adrenal Stress Profile plus V testing includes:
- 4 levels of cortisol throughout the day
- Total cortisol for the day
- DHEA average
- Once we have your test results back in our office the Depke Wellness staff will call you to set up your phone or in office appointment to review your results
- We will provide the necessary recommendations to assist your body in balancing your adrenal function
- We will assist you in uncovering the underlying triggers which are the true causes of your adrenal insufficiency